Stress, Corticoids and Diabetes

authors when insulin was given subcutaneously. In this instance, in contrast to intravenous injection, the slow absorption limits the concentration of insulin in the blood to low levels. In consequence, the results obtained imitated those found following the intravenous injection of tolbutamide, namely, a suppression of glucose entry from the liver into the blood stream shown by plateauing of the specific activity of the blood glucose but no peripheral increase of glucose utilization. Presumably as in the administration of tolbutamide, the concentration of insulin in the blood is increased but its action is limited to the liver. These conclusions, in agreement with those of the other two papers, are in accord with the [3-cytotropic hypothesis of the action of the arylsulfonylureas.